Irina Petrache, M.D.

Irina Petrache, M.D.
Professor of Medicine (BIOM)/Dr. Calvin H. English Professor

Indiana University School of Medicine
(317) 278-0050

Dr. Petrache has developed a successful research program of mechanisms relevant to the development of chronic airways lung diseases such as COPD/emphysema, chronic bronchitis and cystic fibrosis. Her research is evaluating the role of sphingolipids in the development of smoking induced- and other experimental models of emphysema, and in collaboration with Dr. Lahm, in pulmonary hypertension. Her laboratory is also actively studying novel functions of alpha 1 antitrypsin and their disruption in emphysema. Dr. Petrache has a strong background in vascular biology and endothelial cell signaling and apoptosis and she is studying their impact in the development of emphysema, actively collaborating with multiple faculty from the Indiana Center for Vascular biology and Medicine. These collaborations involve the study of novel effects in the lung of pro-apoptotic and pro-inflammatory cytokines, as well as the role of adult adipose stem cells in preventing smoking-induced emphysema, a regenerative therapeutics project developed in collaboration with Dr. March. Collaborative projects of the Petrache lab also involve Dr. Robin Presson’s studies of in vivo lung signaling using fluorescence intravital microscopy. Dr. Petrache’s mentoring accomplishments and commitment to training scientists are listed in the table x. Her currently lab includes three predoctoral trainees, one PhD postdoc and one MD pulmonary fellow, as well as one junior faculty physician scientists. Three technicians and two PhD scientists are also in Petrache’s group.


1481 W. 10th St., C3105 | Indianapolis, IN 46202 | Ph: (317) 988-4976 | Fax: (317) 988-9325