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Maria B. Grant, M.D., FARVO

Maria B. Grant, M.D., FARVO
Marilyn Glick Professor of Ophthalmology
Indiana University, School of Medicine

(317) 274-2628
mabgrant@iu.edu

Dr. Grant’s laboratory has been advancing the field of hematopoietic stem/progenitor biology and the role of circulating angiogenic cells (CACs)/CD34+ cells in physiological and pathological vascular repair in the retina. We are currently characterizing the biochemical basis for CD34+ cell dysfunction in diabetes and are developing a series of strategies to correct this dysfunction so that the cells can be utilized for autologous cell therapy in diabetic subjects with vascular complications that are not amendable to surgery or pharmacological therapy. Dr. Grant has recently found that in both T1D and T2D alterations exist in the neural regulation of hematopoietic progenitor release from the bone marrow and that diabetes is associated with loss of bone marrow innervation. This “bone marrow neuropathy” dramatically affects hematopoiesis leading to reduced generation of vascular progenitors and increased generation of monocytes that ultimately contribute to the pathogenesis of diabetic retinopathy.  Dr. Grant is actively collaborating with Drs. Boulton, March, and Yoder

1481 W. 10th St., C3105 | Indianapolis, IN 46202 | Ph: (317) 988-4976 | Fax: (317) 988-9325